Fucoidans as Potential Therapeutics for Age-Related Macular Degeneration—Current Evidence from In Vitro Research

Age-related macular degeneration (AMD) is the major reason for blindness in the industrialized world with limited treatment options. Important pathogenic pathways in AMD include oxidative stress and vascular endothelial growth factor (VEGF) secretion. Due to their bioactivities, fucoidans have recently been suggested as potential therapeutics. This review gives an overview of the recent developments in this field. Recent studies have characterized several fucoidans from different species, with different molecular characteristics and different extraction methods, in regard to their ability to reduce oxidative stress and inhibit VEGF in AMD-relevant in vitro systems. As shown in these studies, fucoidans exhibit a species dependency in their bioactivity. Additionally, molecular properties such as molecular weight and fucose content are important issues. Fucoidans from Saccharina latissima and Laminaria hyperborea were identified as the most promising candidates for further development. Further research is warranted to establish fucoidans as potential therapeutics for AMD.     

Study of residual stress variation with depth of friction stir welded aluminium plates with different thicknesses

ABSTRACT

The residual stress may greatly vary through thickness due to the large temperature gradients and severe plastic deformation in depth for thick section friction stir welded plates. AA 2024-T351 plates with 6.5, 12 and 20?mm thicknesses were joined by friction stir welding to investigate the differences of residual stress variations with depth between thin and thick plates. The surface residual stresses were compared between the X-ray diffraction and contour measurements. Significant variations of stress peaks, root central residual stresses and widths of ‘M’ profiles were observed along the thickness for thick plates. The origins of the aggravated variations with depth were investigated from the temperature gradients and material flow variations through thickness.     

高速列车转向架构架损伤、等效应力及寿命分布特性研究

为分析高速列车转向架构架损伤、等效应力及寿命分布特性，对构架疲劳关键测点进行动应力线路实测并对测点实测时域数据波形进行解析；基于实测应力时间历程及雨流计数法编制二维应力谱，利用Goodman等寿命方程将二维应力谱等效转换为一维应力谱；阐述线性累积损伤及非线性累积损伤模型的建立方法并对实测数据的线性累积损伤及非线性累积损伤进行了计算及对比分析；分别基于线性累积损伤理论及非线性累积损伤理论推导出各理论下的等效应力，基于实测数据对两种等效应力进行了计算及对比分析；通过结合非线性累积损伤及线性累积损伤理论计算的等效应力及不同可靠度下的材料S-N曲线计算并对比分析构架结构的疲劳寿命。研究结果表明，与非线性疲劳分析理论相比，线性疲劳分析理论对高速列车转向架构架的疲劳特性评估偏于保守。     

Up-pulling force analysis for ESC hollow cylindrical casting

Electroslag casting(ESC)is an important method to produce high quality castings.In this study,the ESC up-pulling inner mold method(EUPIM)was used to produce hollow cylindrical castings with the multiple consumable electrodes.The radial deformation,the axial and radial internal stress of the inner mold,and the axial internal stress of the slag shell were analyzed using the finite element method(FEM)with the aid of ANSYS software.The ProCAST software was used to calculate the specific heat,heat conductivity and density curve of Cu.Simulation results show that the radial deformation,the axial and radial internal stress of the inner mold,and the axial internal stress of the slag shell near the slag-metal interface of hollow cylndrical casting gradually increase from 0 s to 360 s after the ESC starting(slagging)process but before applying the up-pulling force.The suitable initial up-pulling moment of the inner mold is at around 180-198 s after the starting process.     

带耐火衬里高温反应器密封锥结构的设计

耐火衬里及支撑结构设计的可靠性是保证高温反应器壳体温度小于设计温度的关键因素。针对耐火衬里结构失效导致反应器壳体温度超过设计温度的问题,提出了一种双金属焊接的密封锥结构。该结构具有支撑金属衬里的作用以及将耐火材料与金属衬里之间的膨胀空间分割成多个密闭空间以阻止高温气体的流动,进而提高隔热可靠性。采用ANSYS软件中APDL语言建立了密封锥连接结构的有限元模型,通过研究密封锥不同角度以及厚度对计算结果的影响,得出了密封锥的最佳结构参数,并满足ASME标准的应力强度评定要求。模拟结果可为此类高温反应器耐火衬里结构的设计提供参考依据。     

无扩口导管拧紧力矩对其密封性能的影响

以某型飞机中无扩口液压导管为研究对象,结合飞机液压导管实际安装以及保压工况,利用有限元软件ANSYS中多线性随动强化来模拟导管弹塑性本构模型;对处于不同安装力矩以及恒定压力下的导管连接件进行仿真分析,研究安装力矩对导管管接头处的应力应变以及密封性能的影响,并给出参考安装力矩。构建液压导管安装试验台,利用力矩扳手采集拧紧力矩值并使用液压油车对导管进行加压试验,验证不同安装力矩对导管管接头密封性能的影响。结果表明:导管与卡套之间的胀形区域产生的大变形以及应力集中是引起导管管接头渗漏的主要原因之一;所提出的密封性能仿真方法可以较为准确地模拟拧紧力矩与密封性能的关系,为实际工程中导管安装提供依据。     

微织构刀具对工件表面残余应力影响有限元分析

针对微织构刀具对切削工件表面残余应力的影响,设计不同尺寸的垂直槽和平行槽微织构,利用有限元仿真技术,模拟不同类型、不同尺寸微织构PCBN刀具干式车削GCr15试验。通过对有限元结果进行研究分析,得到已加工表面残余应力分布情况,并与无织构PCBN刀具对比,分析微织构对已加工表面残余应力的影响。有限元仿真结果表明:与无织构刀具切削工件表面获得拉应力相比,槽型织构刀具切削后的工件已加工表面呈现压应力,提高工件表层的耐磨损和耐疲劳性能;宽度50μm垂直槽和宽度40μm平行槽刀具切削得到的工件表面压应力最大,对工件表面应力分布影响最显著。     

新型微坑车刀切削AISI4140残余应力影响因素分析研究

为了探究切削用量对新型微坑车刀切削工件表面残余应力的影响规律,应用AdvantEdge切削仿真软件,结合单因素和正交实验,通过微坑车刀和原车刀切削AISI_4140仿真及实验验证。结果表明,原车刀和微坑车刀残余拉应力随切削速度增大,先增大后减小,随进给量的增大而减小,总体上,微坑车刀切削工件残余拉应力更小。残余压应力随切削速度增大,微坑车刀切削工件先增大后减小,随进给量增大先增大后减小。原车刀几乎不变。切削用量对微坑车刀切削工件残余应力影响,进给量最大,切削速度次之,切削深度最小。通过实验验证,相同切削条件下,微坑车刀降低了加工工件表面残余拉应力,提高了加工工件表面质量,一定程度提高了工件的服役寿命。     

直流电对7B04铝合金固溶与时效组织和性能的影响

本文采用拉伸试验、扫描电子显微镜(SEM)和透射电子显微镜(TEM)等手段,研究了7B04铝合金在施加和不施加直流电条件下,经470℃固溶和100-140℃时效处理后的组织和力学性能。与传统的T6处理(470 oC/30 min+120 oC/24h)相比,固溶和/或时效处理时施加500A的电流,可显著提高GPII区的析出密度,进而提高峰时效状态下的拉伸强度和延伸率。固溶过程中施加直流电可将随后时效合金达到峰值强度的时间明显缩短12h。     

微弧氧化Mg-3Al-1Zn镁合金应力腐蚀和腐蚀疲劳行为研究

本文主要对微弧氧化Mg-3Al-1Zn镁合金在空气和3.5 wt.%硫酸钠溶液两种环境下的应力腐蚀和腐蚀疲劳行为进行研究，并讨论其相互关系。微弧氧化处理后，Mg-3Al-1Zn镁合金的耐蚀性能得到明显改善。与Mg-3Al-1Zn镁合金基体相比，在空气中，微弧氧化后合金的应力腐蚀和腐蚀疲劳强度均下降了大约10 MPa。在3.5 wt.%硫酸钠溶液环境中，微弧氧化后合金的腐蚀疲劳性能仍然是恶化的，但是应力腐蚀强度却得到了显著改善，从58.24 MPa提高至202.08 MPa。这表明材料的力学性能（应力腐蚀和腐蚀疲劳）并不是与其腐蚀性能完全保持线性关系的。微弧氧化处理后镁合金在空气中的应力腐蚀断口为韧性断裂，在硫酸钠溶液环境中为解理断裂。而其腐蚀疲劳断口不论是在空气中还是在腐蚀环境中均为解理断裂。这主要是由于腐蚀环境和变换循环载荷的影响，两者共同作用将会加速裂纹扩展。这表明，周围环境和加载类型对材料断裂机理有重要影响。